Tatsuya Tokura Selected Research

Duloxetine Hydrochloride (Cymbalta)

1/2024	Duloxetine improves chronic orofacial pain and comorbid depressive symptoms in association with reduction of serotonin transporter protein through upregulation of ubiquitinated serotonin transporter protein.
1/2022	Duloxetine attenuates pain in association with downregulation of platelet serotonin transporter in patients with burning mouth syndrome and atypical odontalgia.
1/2019	Effect of antidepressant treatment on plasma levels of neuroinflammation-associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region.
7/2017	Duloxetine Plasma Concentrations and Its Effectiveness in the Treatment of Nonorganic Chronic Pain in the Orofacial Region.
7/2015	Five Patients With Burning Mouth Syndrome in Whom an Antidepressant (Serotonin-Noradrenaline Reuptake Inhibitor) Was Not Effective, but Pregabalin Markedly Relieved Pain.
11/2012	Effectiveness of duloxetine for the treatment of chronic nonorganic orofacial pain.

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Tatsuya Tokura Research Topics

Disease

6	Pain (Aches) 01/2024 - 11/2012
4	Burning Mouth Syndrome (Syndrome, Burning Mouth) 01/2022 - 11/2012
3	Facial Pain (Myofacial Pain) 01/2024 - 05/2012
3	Toothache (Toothaches) 01/2022 - 11/2012
3	Chronic Pain 01/2020 - 05/2012
1	Head and Neck Neoplasms (Head and Neck Cancer) 04/2024
1	Alcoholic Liver Diseases (Alcoholic Liver Disease) 11/2021
1	Major Depressive Disorder (Major Depressive Disorders) 01/2020
1	Inflammation (Inflammations) 01/2020
1	Medically Unexplained Symptoms 01/2019
1	Neuroinflammatory Diseases 01/2019
1	Neuralgia (Stump Neuralgia) 07/2015

Drug/Important Bio-Agent (IBA)

6	Duloxetine Hydrochloride (Cymbalta)FDA Link 01/2024 - 11/2012
2	Serotonin (5 Hydroxytryptamine)IBA 01/2024 - 07/2015
2	Proteins (Proteins, Gene)FDA Link 01/2024 - 01/2022
2	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA 01/2024 - 01/2022
2	Antidepressive Agents (Antidepressants)IBA 01/2019 - 07/2015
2	Milnacipran (Ixel)FDA Link 07/2015 - 05/2012
1	KynurenineIBA 01/2020
1	anthranilic acid (anthranilate)IBA 01/2020
1	Kynurenic Acid (Kynurenate)IBA 01/2020
1	3-hydroxykynurenineIBA 01/2020
1	Tryptophan (L-Tryptophan)FDA Link 01/2020
1	3-Hydroxyanthranilic AcidIBA 01/2020
1	Biomarkers (Surrogate Marker)IBA 01/2020
1	Anticonvulsants (Antiepileptic Drugs)IBA 07/2015
1	Amitriptyline (Elavil)FDA LinkGeneric 07/2015
1	Nortriptyline (Aventyl)FDA LinkGeneric 07/2015
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 07/2015
1	Pregabalin (Lyrica)FDA Link 07/2015
1	Calcium Channels (Calcium Channel)IBA 07/2015
1	Serotonin and Noradrenaline Reuptake InhibitorsIBA 07/2015
1	LigandsIBA 07/2015
1	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA 07/2015
1	Analgesics (Analgesic Drugs)IBA 05/2012

Therapy/Procedure

1	Laryngectomy 04/2024
1	Liver Transplantation 11/2021
1	Therapeutics 07/2015